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    William Heberden. "Some Account of a Disorder of the Breast." in Medical Transactions, Published by the College of Physicians in London, Volume the Second, pages 59-67. London: Printed for S. Baker & J. Dodsley, 1772. First edition of Heberden's classic description of angina pectoris. Octavo (8.125 x 4.875 inches; 206 x 125 mm.). Volume II only. xv, [1, blank], 533 pp, [1, blank], [1, errata], [1, blank] pages (note: the "2" in the pagination of page 216 is printed upside down; page 531 incorrectly numbered 431). Contemporary sprinkled calf with gilt double fillet border on covers; neatly rebacked with light brown calf, the spine ruled in gilt with five raised bands and the original burgundy leather label decoratively tooled and lettered in gilt; top edge appears to have been stained black, others sprinkled red. Three of four corners renewed (all but the lower corner of the front cover); original covers quite worn and damaged near the spine; several areas of surface loss, with boards exposed on edges and lower corner of front cover; several scratches and scuff marks; a few dark stains. Front free endpaper reinserted. Over-opened at gathering B, with leaves B1-B7 (pages [1]-14) detached and loosely laid in; dark ink spot or adhesion on page 223; ink spot or mark at inner edge of page 325; early ink corrections on page 333 and page 492. Occasional marginal smudging or soiling; a few mostly marginal small stains. Bookplate of Irving Addison Beck, M.D., Providence, Rhode Island, on front pastedown. A very good copy. The Evan Bedford Library of Cardiology 42; Garrison-Morton 2887; Norman Library 1033; Osler 2913.

    More Information: This volume also contains five additional papers by Heberden: I. "Of the Hectic Fever...Read at the College, July 7, 1768" (pages [1]-17); II. "Remarks of the Pulse...Read at the College, July 7, 1768" (pages 18-33); X. "Of the Diseases of the Liver...Read at the College, August 15, 1769" (pages 123-172); XI. "Of the Nettle rash...Read at the College, August 15, 1770" (pages 173-191); XIV. "An account of the noxious effects of some Fungi...Read at the College, October 31, 1770" (pages 216-221); as well as: XXIII. "Queries...Read at the College, July 21, 1768. Query I" (pages 499-505); "Query II" (pages 506-520); "Query III...Read at the College, August 15, 1770" (pages 521-528); "Query IV. On opening a Vein in Haemorrhages...Read at the College, December 11, 1771" (pages 529-533).

    "This classic description of angina pectoris is the substance of a paper read on July 21, 1768. Although descriptions of angina are to be found in the works of earlier writers, these mention only dyspnoea in their cases. The merit of Heberden's account (in which, incidentally, he used the name 'angina pectoris') lies in the fact that he was the first to include a description of the paroxysmal oppression in the thorax. His account is so perfect that it might well have been written today" (Garrison-Morton).

    "Heberden's paper on angina pectoris covered only nine pages, printed in large type, and probably the most concise and precise original description of a new disease in the history of medicine. It was read on 21st July, 1768, but not published until 1772. Besides effort pain, he described the more prolonged nocturnal attacks and mentioned a case in which pain persisted several days when the patient's life was in peril, obviously a case of cardiac infarction" (Bedford).

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