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    Francis Harry Compton Crick and James Dewey Watson. "Molecular Structure of Nucleic Acids. A Structure for Deoxyribose Nucleic Acid." [Together with:] Maurice F. H. Wilkins, Alexander R. Stokes, and Herbert R. Wilson. "Molecular Structure of Deoxypentose Nucleic Acids." [And:] Rosalind E. Franklin and Ray G. Gosling. "Molecular Configuration in Sodium Thymonucleate." in Nature 171, No. 4356, April 25, 1953, pages 737-741. [And:] Francis Harry Compton Crick and James Dewey Watson. "Genetical Implications of the Structure of Deoxyribonucleic Acid." in Nature 171, No. 4361, May 30, 1953, pages 964-967. London: Macmillan and Co., [1953]. First edition of the first announcement of Watson and Crick's discovery of the structure of DNA. Signed by Francis Crick on page 738 (at the end of the article "A Structure for Deoxyribose Nucleic Acid"), and on page 964 (at beginning of article "Genetical Implications of the Structure of Deoxyribonucleic Acid"). Large octavo (9.625 x 6.75 inches; 245 x 173 mm.). Whole volume collation: lxiv, 404, clvii-clviii (advertisements), [405]-1168 pages. "Name Index" (pages iii-xxxiii); "Title Index" (pages xxxiv-lxiv). Text in double columns. These papers contain four Illustrations: two line-drawn illustrations (including the double helix) and two halftone illustrations (including the famous x-ray photograph of DNA). Volume 171 of Nature: A Weekly Journal Science, contains January 3, 1953, to June 27, 1953. Modern half maroon calf, ruled in gilt and blind, over marbled paper boards, spine ruled in gilt and blind and lettered in gilt in compartments, with five slightly raised bands decoratively tooled in gilt; top edge gilt, others sprinkled brown. Stamp-signed in black with the initials "D W" on rear pastedown (most likely the binder David Weinstein); an area of slight darkening on the spine. Very occasional marginal smudging or soiling; several leaves with slight vertical crease; a few corner tips creased or folded; short tear and two small pieces folded in (paper flaw) in the outer margin of pages 929/930 and 931/932; a few additional tiny edge tears or nicks. Black ink library stamp at foot of title-page, and on pages 63 and 1167: "Univ. of Tulsa Library / Tulsa, Oklahoma;" pencil note: "T. U. / Tulsa / Lat 66;" pencil volume number in the upper margin of page iii (Index). On page 804, the price "£6" has been circled in red pencil. This important work is in near fine condition, with only minor flaws. Protected in a russet cloth chemise and quarter russet calf over marbled board slipcase. Dibner, Heralds of Science, 200; Garrison-Morton 256.3, 7138, and 6847; Heirs of Hippocrates 2342; Grolier, Medicine, 99.

    More Information: "This paper ['A Structure for Deoxyribose Nucleic Acid'] by James D. Watson and Francis H. C. Crick records the discovery of the molecular structure of deoxyribonucleic acid (DNA), the main component of chromosomes and the material that transfers genetic characteristics in all life forms. Publication of this paper initiated the science of molecular biology. Forty years after Watson and Crick's discovery, so much of the basic understanding of medicine and disease has advanced to the molecular level that their paper may be considered the most significant single contribution to biology and medicine in the twentieth century...When Watson and Crick's paper was submitted for publication in Nature, Sir Lawrence Bragg, the director of the Cavendish Laboratory at Cambridge, and Sir John Randall of King's College agreed that the paper should be published simultaneously with those of two other groups of researchers who had also prepared important papers on DNA: Maurice Wilkins, A. R. Stokes, and H. R. Wilson, authors of 'Molecular Structure of Deoxypentose Nucleic Acids,' and Rosalind Franklin and Raymond Gosling, who submitted the paper 'Molecular Configuration in Sodium Thymonucleate.' The three papers were published in Nature under the general title 'The Molecular Structure of Nucleic Acids.' Shortly afterwards, Watson and Crick published their paper 'Genetical Implications of the Structure of Deoxyribonucleic Acid,' in which they elaborated on their proposed DNA replication mechanism" (Grolier, Medicine).

    "The Nobel Prize in Physiology or Medicine 1962 was awarded jointly to Francis Harry Compton Crick, James Dewey Watson and Maurice Hugh Frederick Wilkins "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material" (https://www.nobelprize.org/prizes/medicine/1962/summary/).


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